Recepteurs steroidiens

We screened for the prognostic value of estrogen receptor (ER) and progesterone receptor (PR) through a multicentric study of 2,257 operable breast cancer patients who did not received adjuvant therapy. Three hundred and seven local-regional recurrences, 105 metachronous contralateral breast cancer, 589 metastases and 537 deaths from cancer had been diagnosed with a median follow-up of years. A total of 69% of the tumors were ER positive and 54% PR positive. For statistical analysis, 1,665 patients were studied because of complete clinical and biological data. In univariate analysis, ER and PR status were of prognostic value for the metastases-free interval (MFI) and the overall survival (OS). In multivariate analysis (Cox proportional hazard model), only the ER status showed a significant difference between positive and negative groups regarding the MFI and OS. By using Cox regression model with time-dependent covariates, we show that the predictive value of ER status of the primary tumor decreases by approximately 20% per year, losing its significance after 8 years of follow-up. These results show that ER and PR status have a relatively limited predictive value and their major interest remain in the domain of therapeutic decision.

Der Nachweis der Expression des erfindungsgem·assen Polypeptids kann auch ·uber den Nachweis von mRNA in den Zellen erfolgen. Gegenstand der Erfindung ist daher auch die Verwendung einer Sonde mit Nukleins·auresequenzen, die komplement·ar zu den Nukleins·auresequenzen sind, die f·ur die erfindungsgem·assen Peptide kodieren, zur Herstellung eines Reagenz zum Nachweis der Gegenwart von erfindungsgem·asser mRNA in Zellen. Eine Sonde ist ein kurzes DNA-St·uck mit mindestens 14 Nukleotiden. Die erfindungsgem·assen Sonden k·onnen . in einer Northern Blot Analyse verwendet werden. Diese Methode ist . in Sambrook, J. et al., 1989, Cold Spring Harbor Laboratory Press, beschrieben. Andere Methoden zum Nachweis der RNA sind In Situ Hybridisierung, RNAse Protection Assay oder PCR.

Recepteurs steroidiens

recepteurs steroidiens


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