Glucocorticoids and mineralocorticosteroids

[Continued from above] . . first line of defense and response to physical and emotional stresses. The adrenal glands are shaped like the French Emperor Napoleon's hat and, just as Napoleon's three-cornered hat sat on his head, so each gland is perched on each of the kidneys. These glands are about one to two inches in length; they weigh only a fraction of an ounce each yet are among the most productive of all of the body's glands, secreting more than three dozen hormones. The adrenal cortex takes instruction from the pituitary glands and have important effects on physical characteristics, development and growth. The adrenal gland has two parts. The cortex, or outer, yellow layer, takes its instructions from the pituitary hormone ACTH. The hormones secreted here are called steroids and have three main types: those which control the balance of sodium and potassium in the body; those which raise the level of sugar in the blood; and sex hormones. The inner, reddish brown layer of the adrenal gland (the adrenal medulla) makes two types of hormones; this part of the adrenal gland takes its instruction from the nervous system, producing chemicals which react to fear and anger and are sometimes called fight or flight hormones.

Glucocorticoids are potent anti-inflammatories, regardless of the inflammation's cause; their primary anti-inflammatory mechanism is lipocortin-1 (annexin-1) synthesis. Lipocortin-1 both suppresses phospholipase A2 , thereby blocking eicosanoid production, and inhibits various leukocyte inflammatory events ( epithelial adhesion , emigration , chemotaxis , phagocytosis , respiratory burst , etc.). In other words, glucocorticoids not only suppress immune response, but also inhibit the two main products of inflammation, prostaglandins and leukotrienes . They inhibit prostaglandin synthesis at the level of phospholipase A2 as well as at the level of cyclooxygenase /PGE isomerase (COX-1 and COX-2), [29] the latter effect being much like that of NSAIDs , potentiating the anti-inflammatory effect.

Glucocorticoids and mineralocorticosteroids

glucocorticoids and mineralocorticosteroids


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