Fluorinated steroids names

Clobetasol propionate at concentrations up to % did not increase the rate of formation of ultra violet light-induced skin tumors when topically applied to hairless mice 5 days per week for a period of 40 weeks.
Clobetasol propionate was negative in the in vitro mammalian chromosomal aberration test and in the in vivo mammalian erythrocyte micronucleus test

The effect of subcutaneously administered clobetasol propionate on fertility and general reproductive toxicity was studied in rats at doses of 0, , 25, and 50 μg/kg/day. Males were treated beginning 70 days before mating and females beginning 15 days before mating through day 7 of gestation. A dosage level of less than μg/kg/day clobetasol propionate was considered to be the no-observed-effect-level (NOEL) for paternal and maternal general toxicity based on decreased weight gain and for male reproductive toxicity based on increased weights of the seminal vesicles with fluid. The female reproductive NOEL was μg/kg/day (ratio of animal dose to proposed human dose of on a mg/m 2 /day basis) based on reduction in the numbers of estrous cycles during the pre-cohabitation period and an increase in the number of nonviable embryos at higher doses.

In photoallergic dermatitis, sunlight and exposure to the offending substance usually affect the face and arms, but the sun-shaded area under the chin is generally spared. Although sunlight is essential for the initiation of photosensitization, the dermatitis may continue long after the photoallergy is eliminated (a condition known as a “persistent light eruption”). 9 Common photoallergic substances include fruits and vegetables (., limes, celery, parsnips), hydrocarbons (., coal tar, pitch, asphalt, anthracene), and drugs (., tetracycline, thiazide diuretics, phenothiazines, sulfonamides) and fluorescein dye. 3

Fluorinated steroids names

fluorinated steroids names


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