Acne is often present. Acne conglobata is a particularly severe form of acne that can develop during steroid abuse or even after the drug has been discontinued. Infections are a common side effect of steroid abuse because of needle sharing and unsanitary techniques used when injecting the drugs into the skin. These are similar risks to IV drug abusers with increased potential to acquire blood-borne infections such as hepatitis and HIV/AIDS . Skin abscesses may occur at injection sites and may spread to other organs of the body. Endocarditis or an infection of the heart valves is not uncommon.
Last year I developed a rash under my eyes and I was promptly prescribed hydrocortisone cream. It didn't help much and the doctor referred me to see a dermatologist. I was told to keep using the hydrocortisone and I was discharged. As the steroid cream didn't help I searched the internet for another remedy and that's how I came across a product called Magicream. It claims it only contains natural ingredients and it promised to clear up my rash. I was so excited! I have recently found out that the cream in fact contains Clobetasol Propionate and Ketoconazole. I was devastated to find this out especially since side effects include red spots and a burning sensation! When I stopped using the cream the side effects were terrible - I don't need to tell you as you know how the withdrawal of steroid can affect ones face. I then did a search on line and found your website which made so much sense and helped me to understand what was happening with my skin. I ordered the Face & Body Wash and the Face & Neck TheraCream and I have been symptom FREE ever since. Thank you from a once frustrated person!! Trish Managold, UK
Corticosteroids have been used as drug treatment for some time. Lewis Sarett of Merck & Co. was the first to synthesize cortisone, using a complicated 36-step process that started with deoxycholic acid, which was extracted from ox bile .  The low efficiency of converting deoxycholic acid into cortisone led to a cost of US $200 per gram. Russell Marker , at Syntex , discovered a much cheaper and more convenient starting material, diosgenin from wild Mexican yams . His conversion of diosgenin into progesterone by a four-step process now known as Marker degradation was an important step in mass production of all steroidal hormones, including cortisone and chemicals used in hormonal contraception .  In 1952, . Peterson and . Murray of Upjohn developed a process that used Rhizopus mold to oxidize progesterone into a compound that was readily converted to cortisone.  The ability to cheaply synthesize large quantities of cortisone from the diosgenin in yams resulted in a rapid drop in price to US $6 per gram, falling to $ per gram by 1980. Percy Julian's research also aided progress in the field.  The exact nature of cortisone's anti-inflammatory action remained a mystery for years after, however, until the leukocyte adhesion cascade and the role of phospholipase A2 in the production of prostaglandins and leukotrienes was fully understood in the early 1980s.