Effect of alpha lipoic acid on oxidative stress and vascular wall of diabetic rats.
Rom J Morphol Embryol. 2009.
The aim of the present study was to investigate the effect of alpha lipoic acid supplementation on plasma lipid, oxidative stress and vascular changes in diabetic rats. It is concluded that alpha lipoic acid has the potential in preventing the alteration of vascular morphology in diabetic rats probably through the improvement of blood sugar status and lipid cholesterol issues as well as its antioxidant activities.
Anyone interested in alpha-lipoic acid should read Dr. Burt Berkson’s book The Alpha-Lipoic Acid Breakthrough. I am a patient of Dr. Berkson’s and follow his protocols for both oral and IV alpha-lipoic acid supplementation. Dr. Berkson’s ALA regimen helped bring me back from decompensated liver cirrhosis to almost normal health in 18 months. I still have some symptoms and evidence of cirrhosis but have so much improved that I am able to live and work normally. Dr. Berkson emphasizes that not all ALA supplementation is equal and you should be careful that you get a pharmaceutical grade of of ALA with consistent dosages and that all ALA supplementation should be taken with B Complex vitamin supplementation. I personally take 900 mg orally each day and 600 mg IV 2 times a week and have experienced no adverse side effects or reactions other than restless legs.
Glutathione is considered the “master antioxidant” by many experts, since it’s crucial for immunity, cellular health and disease prevention. Some studies have found that 300–1,200 milligrams of alpha lipoic acid helps increase the ability of glutathione to regulate the body’s immune response and fight off diseases like diabetes/ insulin resistance or even HIV/AIDS. ( 8 ) In adults, supplementation with alpha lipoic acid seems to positively impact patients with immune deficiency syndromes and serious viruses by restoring blood total glutathione levels and improving functional reactivity of lymphocytes to T-cell mitogens.